Assay Detail
Functional
CHEMBL928637
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Antiproliferative activity against human GTL16 cells after 72 hrs by tetrazolium-based colorimetric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GTL 16 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.67 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438696 | — | — | 1 | 7.17 |
| CHEMBL254086 | — | — | 1 | 6.85 |
| CHEMBL400332 | — | — | 1 | 6.77 |
| CHEMBL254280 | — | — | 1 | 6.57 |
| CHEMBL251782 | — | — | 1 | 6.57 |
| CHEMBL254879 | — | — | 1 | 6.08 |
| CHEMBL255092 | — | — | 1 | - |
| CHEMBL255091 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438696 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL254086 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL400332 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL254280 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL251782 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL254879 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL255092 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL255091 | — | IC50 | > | 1000.0 | nM | - |