Assay Detail
Binding
CHEMBL928665
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Binding affinity to MC4 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of 3-arylpyrrolidine-2-carboxamide derivatives as melanocortin-4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.14 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386259 | — | — | 1 | 7.58 |
| CHEMBL425962 | — | — | 1 | 7.51 |
| CHEMBL393715 | — | — | 1 | 7.41 |
| CHEMBL213738 | — | — | 1 | 7.13 |
| CHEMBL251784 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386259 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL425962 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL393715 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL213738 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL251784 | — | Ki | = | 810.0 | nM | 6.09 |