Assay Detail
Binding
CHEMBL928869
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Inhibition of TrkA
37
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.06 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254895 | — | — | 1 | 9.22 |
| CHEMBL251796 | — | — | 1 | 9.00 |
| CHEMBL251795 | — | — | 1 | 9.00 |
| CHEMBL254050 | — | — | 2 | 9.00 |
| CHEMBL254267 | — | — | 1 | 8.70 |
| CHEMBL254268 | — | — | 1 | 8.00 |
| CHEMBL254690 | — | — | 1 | 7.68 |
| CHEMBL254269 | — | — | 1 | 7.51 |
| CHEMBL253858 | — | — | 1 | 7.36 |
| CHEMBL253847 | — | — | 1 | 7.30 |
| CHEMBL254478 | — | — | 1 | 7.22 |
| CHEMBL403342 | — | — | 1 | 7.19 |
| CHEMBL430406 | — | — | 1 | 7.17 |
| CHEMBL253635 | — | — | 1 | 7.10 |
| CHEMBL254894 | — | — | 1 | 6.82 |
| CHEMBL403344 | — | — | 1 | 6.80 |
| CHEMBL254061 | — | — | 1 | 6.72 |
| CHEMBL254688 | — | — | 1 | 6.68 |
| CHEMBL254893 | — | — | 1 | 6.64 |
| CHEMBL212269 | — | — | 1 | 6.62 |
| CHEMBL254062 | — | — | 1 | 6.50 |
| CHEMBL251789 | — | — | 1 | 6.28 |
| CHEMBL427892 | — | — | 1 | 6.14 |
| CHEMBL442438 | — | — | 1 | 6.12 |
| CHEMBL253856 | — | — | 1 | 6.10 |
| CHEMBL254689 | — | — | 1 | 6.04 |
| CHEMBL254479 | — | — | 1 | 5.96 |
| CHEMBL438697 | — | — | 1 | 5.96 |
| CHEMBL254060 | — | — | 1 | 5.92 |
| CHEMBL398474 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254895 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL251796 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL254050 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL254050 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL251795 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL254267 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL254268 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL254690 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL254269 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL253858 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL253847 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL254478 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL403342 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL430406 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL253635 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL254894 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL403344 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL254061 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL254688 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL254893 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL212269 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL254062 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL251789 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL427892 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL442438 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL253856 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL254689 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL438697 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL254479 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL254060 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL398474 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL398473 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL253857 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL253636 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL253855 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL401374 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL403343 | — | IC50 | > | 5000.0 | nM | - |