Assay Detail
Functional
CHEMBL928871
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Antiproliferative activity against TrkA deficient rat RK3E cells after 3 days
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RK3E |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.49 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254050 | — | — | 1 | 5.64 |
| CHEMBL254267 | — | — | 1 | 5.52 |
| CHEMBL254269 | — | — | 1 | 5.51 |
| CHEMBL254268 | — | — | 1 | 5.48 |
| CHEMBL251795 | — | — | 1 | 5.45 |
| CHEMBL251796 | — | — | 1 | 5.44 |
| CHEMBL254895 | — | — | 1 | 5.39 |
| CHEMBL401374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254050 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL254267 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL254269 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL254268 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL251795 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL251796 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL254895 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL401374 | — | IC50 | > | 10000.0 | nM | - |