Assay Detail
Functional
CHEMBL928872
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Antiproliferative activity against human SH-SY5Y cells after 3 days
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254267 | — | — | 1 | 6.12 |
| CHEMBL254050 | — | — | 1 | 5.94 |
| CHEMBL254268 | — | — | 1 | 5.93 |
| CHEMBL254269 | — | — | 1 | 5.78 |
| CHEMBL251796 | — | — | 1 | 5.75 |
| CHEMBL254895 | — | — | 1 | 5.51 |
| CHEMBL251795 | — | — | 1 | 5.37 |
| CHEMBL401374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254267 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL254050 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL254268 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL254269 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL251796 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL254895 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL251795 | — | IC50 | = | 4260.0 | nM | 5.37 |
| CHEMBL401374 | — | IC50 | > | 10000.0 | nM | - |