Assay Detail
Functional
CHEMBL929043
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 trypomastigotes by microplate assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.79 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL255731 | — | — | 1 | 7.30 |
| CHEMBL255101 | — | — | 1 | 7.19 |
| CHEMBL255729 | — | — | 1 | 7.10 |
| CHEMBL256155 | — | — | 1 | 7.10 |
| CHEMBL401810 | — | — | 1 | 6.85 |
| CHEMBL255730 | — | — | 1 | 6.82 |
| CHEMBL255314 | — | — | 1 | 6.68 |
| CHEMBL255944 | — | — | 1 | 6.66 |
| CHEMBL255732 | — | — | 1 | 6.62 |
| CHEMBL255942 | — | — | 1 | 6.54 |
| CHEMBL255946 | — | — | 1 | 6.52 |
| CHEMBL255512 | — | — | 1 | 6.51 |
| CHEMBL255945 | — | — | 1 | 6.44 |
| CHEMBL255943 | — | — | 1 | 6.43 |
| CHEMBL254950 | — | — | 1 | 6.41 |
| CHEMBL254749 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL255731 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL255101 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL255729 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL256155 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL401810 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL255730 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL255314 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL255944 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL255732 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL255942 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL255946 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL255512 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL255945 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL255943 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL254950 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL254749 | — | IC50 | = | 510.0 | nM | 6.29 |