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Assay Detail

CHEMBL929046

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.
Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A.
Bioorg Med Chem Lett (2008) 18 : 2272 -2276
PubMed 18353643 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.45 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL255731 1 6.00
CHEMBL255729 1 5.95
CHEMBL255101 1 5.70
CHEMBL255732 1 5.70
CHEMBL401810 1 5.66
CHEMBL255730 1 5.59
CHEMBL255314 1 5.58
CHEMBL255512 1 5.38
CHEMBL255943 1 5.34
CHEMBL255945 1 5.33
CHEMBL255946 1 5.31
CHEMBL255942 1 5.29
CHEMBL255944 1 5.28
CHEMBL254950 1 5.26
CHEMBL256155 1 5.23
CHEMBL254749 1 4.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL255731 IC50 = 1000.0 nM 6.00
CHEMBL255729 IC50 = 1130.0 nM 5.95
CHEMBL255101 IC50 = 2010.0 nM 5.70
CHEMBL255732 IC50 = 1980.0 nM 5.70
CHEMBL401810 IC50 = 2190.0 nM 5.66
CHEMBL255730 IC50 = 2560.0 nM 5.59
CHEMBL255314 IC50 = 2640.0 nM 5.58
CHEMBL255512 IC50 = 4130.0 nM 5.38
CHEMBL255943 IC50 = 4580.0 nM 5.34
CHEMBL255945 IC50 = 4660.0 nM 5.33
CHEMBL255946 IC50 = 4920.0 nM 5.31
CHEMBL255942 IC50 = 5180.0 nM 5.29
CHEMBL255944 IC50 = 5260.0 nM 5.28
CHEMBL254950 IC50 = 5510.0 nM 5.26
CHEMBL256155 IC50 = 5920.0 nM 5.23
CHEMBL254749 IC50 = 28500.0 nM 4.54