Assay Detail

CHEMBL929142

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Binding

Binding affinity to human recombinant RNase L

ChEMBL ↗

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Target

2-5A-dependent ribonuclease (CHEMBL3575) ↗

Open DB target context

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2-5A-dependent ribonuclease (CHEMBL3575) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 2-5A-dependent ribonuclease

CHEMBL3575

Anchored from Assay target.

Protein identity 2-5A-dependent ribonuclease

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

2-5A-dependent ribonuclease (CHEMBL3575) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Small-molecule activators of RNase L with broad-spectrum antiviral activity.

Thakur CS, Jha BK, Dong B, Das Gupta J, Silverman KM, Mao H, Sawai H, Nakamura AO, Banerjee AK, Gudkov A, Silverman RH.
Proc Natl Acad Sci U S A (2007) 104 : 9585 -9590
PubMed 17535916 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	10.40	10.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL404038	—	—	1	10.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL404038	—	Kd	=	0.04	nM	10.40