2-5A-dependent ribonuclease · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q05823. Use UniProt Q05823 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q05823 as the stable identity anchor, then attach disease evidence before program review.
2-5A-dependent ribonuclease
Review this target as 2-5A-dependent ribonuclease, mapped to UniProt Q05823. Sequence length is 741 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 2-5A-dependent ribonuclease as ChEMBL target CHEMBL3575, mapped to UniProt Q05823. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 2-5A-dependent ribonuclease is the right protein anchor across sources, using UniProt Q05823 as the stable mapping.
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| Preferred Name | 2-5A-dependent ribonuclease |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q05823 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 2-5A-dependent ribonuclease |
| UniProt Accession | Q05823 |
| Component Type | Protein |
| Sequence Length | 741 aa |
2-5A-dependent ribonuclease
Review this target as 2-5A-dependent ribonuclease, mapped to UniProt Q05823. Sequence length is 741 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL404038 | 10.4 | Kd | 0.04 | Preclinical |
| CHEMBL402676 | 9.89 | EC50 | 0.13 | Preclinical |
| CHEMBL414948 | 9.82 | EC50 | 0.15 | Preclinical |
| CHEMBL214603 | 9.62 | EC50 | 0.24 | Preclinical |
| CHEMBL3817920 | 9.35 | EC50 | 0.45 | Preclinical |
| CHEMBL404038 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL405496 | 9.17 | EC50 | 0.68 | Preclinical |
| CHEMBL384725 | 9.15 | EC50 | 0.7 | Preclinical |
| CHEMBL214603 | 9.14 | IC50 | 0.72 | Preclinical |
| CHEMBL414948 | 8.96 | IC50 | 1.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 20 | 22 | 7.3 |
| cell-based format | 13 | 19 | 6.5 |
| assay format | 9 | 14 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |