Compound Detail
CHEMBL214603
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Cc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)O[C@@H]4[C@H](O)[C@@H](COP(=O)(O)O[C@@H]5[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O[C@H]5n5cnc6c(N)ncnc65)O[C@H]4n4cnc5c(N)ncnc54)[C@@H](O)[C@H]3O)c2n1
Basic Information
| ChEMBL ID | CHEMBL214603 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ISYWJMZRGKKVRB-RKTALREWSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1179.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 9.62
IC50 1 meas. best 9.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease CHEMBL3575 | EC50 | 9.62 | 9.57 | 0.2 | 2 |
| 2-5A-dependent ribonuclease CHEMBL3575 | IC50 | 9.14 | 9.14 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 2-5A-dependent ribonuclease | EC50 | = | 0.24 | nM | 9.62 | Activation of purified recombinant human Ribonuclease L by the compound was meas... | 10714492 |
| 2-5A-dependent ribonuclease | EC50 | = | 0.3 | nM | 9.52 | Activation of purified recombinant human Ribonuclease L by the compound was meas... | 10714492 |
| 2-5A-dependent ribonuclease | IC50 | = | 0.72 | nM | 9.14 | Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]... | 10714492 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10714492 | 10.1016/s0960-894x(99)00703-9 | Unchecked | 4 |
| 10714492 | 10.1016/s0960-894x(99)00703-9 | 2-5A-dependent ribonuclease | 3 |
Data from ChEMBL 36 via Core Engine