Assay Detail
Binding
CHEMBL795209
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Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-Methyladenosine-Substituted 2',5'-oligoadenylates: conformations, 2-5A binding and catalytic activities with human ribonuclease L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.67 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL214603 | — | — | 1 | 9.14 |
| CHEMBL402676 | — | — | 1 | 8.59 |
| CHEMBL414948 | — | — | 1 | 8.14 |
| CHEMBL405496 | — | — | 1 | 7.62 |
| CHEMBL384725 | — | — | 1 | 7.24 |
| CHEMBL410213 | — | — | 1 | 6.98 |
| CHEMBL407239 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL214603 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL402676 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL414948 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL405496 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL384725 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL410213 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL407239 | — | IC50 | = | 1060.0 | nM | 5.97 |