Assay Detail
Binding
CHEMBL795208
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Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-Methyladenosine-Substituted 2',5'-oligoadenylates: conformations, 2-5A binding and catalytic activities with human ribonuclease L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.10 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402676 | — | — | 1 | 9.89 |
| CHEMBL414948 | — | — | 1 | 9.82 |
| CHEMBL214603 | — | — | 1 | 9.62 |
| CHEMBL405496 | — | — | 1 | 9.17 |
| CHEMBL384725 | — | — | 1 | 9.08 |
| CHEMBL410213 | — | — | 1 | 8.34 |
| CHEMBL407239 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402676 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL414948 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL214603 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL405496 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL384725 | — | EC50 | = | 0.84 | nM | 9.08 |
| CHEMBL410213 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL407239 | — | EC50 | = | 16.0 | nM | 7.80 |