Assay Detail
Binding
CHEMBL929237
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Inhibition of human cathepsin L
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.45 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259379 | — | — | 1 | 8.44 |
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | — | 1 | 8.13 |
| CHEMBL407264 | — | — | 1 | 8.03 |
| CHEMBL260921 | — | — | 1 | 8.00 |
| CHEMBL261438 | — | — | 1 | 7.96 |
| CHEMBL410086 | — | — | 1 | 7.77 |
| CHEMBL258588 | — | — | 1 | 7.68 |
| CHEMBL406601 | — | — | 1 | 7.41 |
| CHEMBL261307 | — | — | 1 | 7.36 |
| CHEMBL404938 | — | — | 1 | 7.09 |
| CHEMBL261218 | — | — | 1 | 6.93 |
| CHEMBL429858 | — | — | 1 | 6.04 |
| CHEMBL402465 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259379 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL407264 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL260921 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL261438 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL410086 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL258588 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL406601 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL261307 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL404938 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL261218 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL429858 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL402465 | — | IC50 | = | 1020.0 | nM | 5.99 |