Assay Detail
Binding
CHEMBL929240
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Inhibition of KDR by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Conformation-activity relationship on novel 4-pyridylmethylthio derivatives with antiangiogenic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.40 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101683 | — | — | 1 | 7.70 |
| CHEMBL153843 | — | — | 1 | 7.64 |
| CHEMBL256556 | — | — | 1 | 7.58 |
| CHEMBL75232 | — | — | 1 | 7.43 |
| CHEMBL402002 | — | — | 1 | 7.34 |
| CHEMBL427725 | — | — | 1 | 6.70 |
| CHEMBL256718 | — | — | 1 | - |
| CHEMBL404393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101683 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL153843 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL256556 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL75232 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL402002 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL427725 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL256718 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL404393 | — | IC50 | > | 1000.0 | nM | - |