Compound Detail
CHEMBL427725
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL427725 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XCUUMBWYOUDABQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
344.5
MW (Da)
5.07
ALogP
2
HBA
1
HBD
42.0
PSA (Ų)
0.65
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 200.0 | nM | 6.7 | Inhibition of KDR by ELISA | 18420406 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18420406 | 10.1016/j.bmcl.2008.03.068 | Vascular endothelial growth factor receptor 2 | 1 |
| 18420406 | 10.1016/j.bmcl.2008.03.068 | HUVEC | 1 |
Data from ChEMBL 36 via Core Engine