Assay Detail
Binding
CHEMBL929274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental 17beta-HSD2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL2789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.72 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193726 | — | — | 1 | 6.52 |
| CHEMBL258687 | — | — | 1 | 5.40 |
| CHEMBL195217 | — | — | 1 | 5.25 |
| CHEMBL261427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193726 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL258687 | — | IC50 | = | 4007.0 | nM | 5.40 |
| CHEMBL195217 | — | IC50 | = | 5641.0 | nM | 5.25 |
| CHEMBL261427 | — | IC50 | > | 10000.0 | nM | - |