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Assay Detail

CHEMBL929779

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of gastric acid secretion in rabbit gastric gland assessed as accumulation of 14C]-dimethylaminopyridine
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Gastric gland
Confidence 1 — Organism
Curated By Autocuration

Target

Gastric gland (CHEMBL613448)
Type TISSUE
Organism Oryctolagus cuniculus

Publication

5-Substituted 1H-pyrrolo[3,2-b]pyridines as inhibitors of gastric acid secretion.
Palmer AM, Münch G, Brehm C, Zimmermann PJ, Buhr W, Feth MP, Simon WA.
Bioorg Med Chem (2008) 16 : 1511 -1530
PubMed 17962023 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.40 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL402937 1 6.60
CHEMBL271056 1 6.60
CHEMBL255781 1 6.00
CHEMBL272501 1 5.80
CHEMBL271855 1 5.60
CHEMBL403335 1 5.50
CHEMBL256175 1 5.50
CHEMBL429750 1 5.40
CHEMBL401697 1 5.30
CHEMBL271429 1 5.00
CHEMBL257078 1 5.00
CHEMBL271640 1 4.80
CHEMBL255322 1 4.30
CHEMBL256174 1 4.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL402937 IC50 = 251.19 nM 6.60
CHEMBL271056 IC50 = 251.19 nM 6.60
CHEMBL255781 IC50 = 1000.0 nM 6.00
CHEMBL272501 IC50 = 1584.89 nM 5.80
CHEMBL271855 IC50 = 2511.89 nM 5.60
CHEMBL403335 IC50 = 3162.28 nM 5.50
CHEMBL256175 IC50 = 3162.28 nM 5.50
CHEMBL429750 IC50 = 3981.07 nM 5.40
CHEMBL401697 IC50 = 5011.87 nM 5.30
CHEMBL271429 IC50 = 10000.0 nM 5.00
CHEMBL257078 IC50 = 10000.0 nM 5.00
CHEMBL271640 IC50 = 15848.93 nM 4.80
CHEMBL255322 IC50 = 50118.72 nM 4.30
CHEMBL256174 IC50 = 63095.73 nM 4.20