Assay Detail
Binding
CHEMBL929818
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Inhibition of human recombinant AChE by Ellman method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.22 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244416 | — | — | 1 | 7.75 |
| CHEMBL75121 | — | — | 1 | 7.35 |
| CHEMBL26125 | — | — | 1 | 6.74 |
| CHEMBL271710 | — | — | 1 | 6.49 |
| CHEMBL272700 | — | — | 1 | 6.26 |
| CHEMBL248922 | — | — | 1 | 5.56 |
| CHEMBL270248 | — | — | 1 | 5.37 |
| CHEMBL271709 | — | — | 1 | 5.34 |
| CHEMBL239046 | — | — | 1 | 5.14 |
| CHEMBL407904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244416 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL75121 | — | IC50 | = | 44.5 | nM | 7.35 |
| CHEMBL26125 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL271710 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL272700 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL248922 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL270248 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL271709 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL239046 | — | IC50 | = | 7160.0 | nM | 5.14 |
| CHEMBL407904 | — | IC50 | = | 267000.0 | nM | - |