Assay Detail
Binding
CHEMBL929903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Lck
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.16 | 7.23 |
| Ki | 4 | 6.63 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237127 | — | — | 2 | 7.70 |
| CHEMBL270608 | — | — | 2 | 5.55 |
| CHEMBL273158 | — | — | 2 | - |
| CHEMBL270164 | GW607117X | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237127 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL237127 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL270608 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL270608 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL273158 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL273158 | — | Ki | > | 5400.0 | nM | - |
| CHEMBL270164 | GW607117X | IC50 | > | 16000.0 | nM | - |
| CHEMBL270164 | GW607117X | Ki | > | 5400.0 | nM | - |