Compound Detail
CHEMBL270164
GW607117X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL270164 |
| Name | GW607117X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PMMLSQFPBFKLHH-UHFFFAOYSA-N |
1
Targets
7
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
394.4
MW (Da)
5.14
ALogP
5
HBA
1
HBD
91.8
PSA (Ų)
0.52
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 6.62
IC50 3 meas. best 5.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | Ki | 6.62 | 6.62 | 240.0 | 4 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.82 | 5.82 | 1500.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | Ki | = | 240.0 | nM | 6.62 | Inhibition of p38alpha by fluorescence polarization assay | 17981461 |
| Mitogen-activated protein kinase 14 | Ki | = | 240.0 | nM | 6.62 | Inhibition of purified human p38alpha | 18006306 |
| Mitogen-activated protein kinase 14 | Ki | = | 240.0 | nM | 6.62 | Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{... | 18602262 |
| Mitogen-activated protein kinase 14 | Ki | = | 240.0 | nM | 6.62 | Inhibition of P38alpha MAPK (unknown origin) | 31445234 |
| Mitogen-activated protein kinase 14 | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of p38alpha by fluorescence polarization assay | 17981461 |
| Mitogen-activated protein kinase 14 | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of purified human p38alpha | 18006306 |
| Mitogen-activated protein kinase 14 | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of P38alpha MAPK (unknown origin) | 31445234 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| 31445234 | 10.1016/j.ejmech.2019.111624 | Mitogen-activated protein kinase 14 | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-gamma serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK alpha | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK beta | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-5 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-4 | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-alpha serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C iota type | 2 |
| 18006306 | 10.1016/j.bmcl.2007.10.076 | Tyrosine-protein kinase Lck | 2 |
Data from ChEMBL 36 via Core Engine