Assay Detail
Binding
CHEMBL987298
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human p38alpha by fluorescence polarization
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.87 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477190 | — | — | 1 | 9.22 |
| CHEMBL476996 | — | — | 1 | 8.80 |
| CHEMBL477182 | GW769076X | — | 1 | 8.72 |
| CHEMBL515466 | — | — | 1 | 8.72 |
| CHEMBL476995 | — | — | 1 | 8.68 |
| CHEMBL476141 | — | — | 1 | 8.60 |
| CHEMBL477191 | — | — | 1 | 8.52 |
| CHEMBL476351 | GW775608X | — | 1 | 8.36 |
| CHEMBL478234 | — | — | 1 | 8.34 |
| CHEMBL478656 | — | — | 1 | 8.28 |
| CHEMBL478031 | — | — | 1 | 8.20 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 8.19 |
| CHEMBL514509 | — | — | 1 | 7.96 |
| CHEMBL478649 | — | — | 1 | 7.92 |
| CHEMBL478421 | — | — | 1 | 7.92 |
| CHEMBL515318 | — | — | 1 | 7.85 |
| CHEMBL477583 | GW743024X | — | 1 | 7.82 |
| CHEMBL514207 | — | — | 1 | 7.82 |
| CHEMBL95692 | SB-242235 | — | 1 | 7.44 |
| CHEMBL516264 | — | — | 1 | 7.14 |
| CHEMBL476752 | — | — | 1 | 7.10 |
| CHEMBL477620 | — | — | 1 | 7.00 |
| CHEMBL478225 | — | — | 1 | 6.82 |
| CHEMBL270164 | GW607117X | — | 1 | 6.62 |
| CHEMBL476552 | — | — | 1 | 6.52 |
| CHEMBL476111 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477190 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL476996 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL477182 | GW769076X | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL515466 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL476995 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL476141 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL477191 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL476351 | GW775608X | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL478234 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL478656 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL478031 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL103667 | DORAMAPIMOD | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL514509 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL478649 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL478421 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL515318 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL477583 | GW743024X | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL514207 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL95692 | SB-242235 | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL516264 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL476752 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL477620 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL478225 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL270164 | GW607117X | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL476552 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL476111 | — | Ki | = | 730.0 | nM | 6.14 |