Compound Detail
CHEMBL476351
GW775608X Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL476351 |
| Name | GW775608X |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BOQNSWFZUHQNRG-UHFFFAOYSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
4.29
ALogP
5
HBA
2
HBD
83.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.22
Ki 2 meas. best 8.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | Ki | 8.36 | 8.29 | 4.4 | 2 |
| MAP kinase p38 CHEMBL2094115 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Heat shock protein beta-1 CHEMBL5976 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| PBMC CHEMBL613107 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | Ki | = | 4.4 | nM | 8.36 | Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{... | 18602262 |
| Mitogen-activated protein kinase 14 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of p38alpha phosphorylation in IL-1-alpha-stimulated HLF cells | 18602262 |
| MAP kinase p38 | IC50 | = | 6.0 | nM | 8.22 | Inhibition of MAPK p38 (unknown origin) | 29133046 |
| Mitogen-activated protein kinase 14 | Ki | = | 6.0 | nM | 8.22 | Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRE... | 18602262 |
| Heat shock protein beta-1 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of HSP27 phosphorylation in IL-1-alpha-stimulated HLF cells | 18602262 |
| PBMC | IC50 | = | 270.0 | nM | 6.57 | Inhibition of LPS-stimulated TNFalpha release in human PBMC by ELISA | 18602262 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| 18602262 | 10.1016/j.bmcl.2008.06.028 | Mitogen-activated protein kinase 14 | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Inhibitor of nuclear factor kappa-B kinase subunit alpha | 2 |
| - | 10.6019/CHEMBL1961873 | Inhibitor of nuclear factor kappa-B kinase subunit beta | 2 |
| - | 10.6019/CHEMBL1961873 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase Nek1 | 2 |
| - | 10.6019/CHEMBL1961873 | Sphingosine kinase 2 | 2 |
| - | 10.6019/CHEMBL1961873 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2 |
| - | 10.6019/CHEMBL1961873 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 2 |
| 18602262 | 10.1016/j.bmcl.2008.06.028 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine