Assay Detail
Functional
CHEMBL987303
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Inhibition of LPS-stimulated TNFalpha release in human PBMC by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.78 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.52 |
| CHEMBL476141 | — | — | 1 | 7.05 |
| CHEMBL95692 | SB-242235 | — | 1 | 6.77 |
| CHEMBL478649 | — | — | 1 | 6.60 |
| CHEMBL476351 | GW775608X | — | 1 | 6.57 |
| CHEMBL477583 | GW743024X | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL476141 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL95692 | SB-242235 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL478649 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL476351 | GW775608X | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL477583 | GW743024X | IC50 | = | 650.0 | nM | 6.19 |