Compound Detail
CHEMBL95692
SB-242235 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL95692 |
| Name | SB-242235 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PDTYLGXVBIWRIM-UHFFFAOYSA-N |
12
Targets
15
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
3.08
ALogP
6
HBA
1
HBD
64.9
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 8 meas. best 7.7
IC50 7 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C beta type CHEMBL3045 | IC50 | 7.77 | 7.77 | 17.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.72 | 7.3367 | 19.0 | 3 |
| Casein kinase I isoform delta CHEMBL2828 | Ki | 7.7 | 7.7 | 19.9 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | Ki | 7.44 | 7.44 | 36.0 | 1 |
| Protein kinase C alpha type CHEMBL299 | IC50 | 7.08 | 7.08 | 83.0 | 1 |
| Heat shock protein beta-1 CHEMBL5976 | IC50 | 6.8 | 6.8 | 160.0 | 1 |
| PBMC CHEMBL613107 | IC50 | 6.77 | 6.77 | 170.0 | 1 |
| Casein kinase I isoform alpha CHEMBL2793 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 4 CHEMBL6166 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha CHEMBL4101 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 5 CHEMBL4852 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Serine/threonine-protein kinase D3 CHEMBL2595 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
| Misshapen-like kinase 1 CHEMBL5518 | Ki | 5.4 | 5.4 | 3981.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine