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Assay Detail

CHEMBL1963835

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA
ChEMBL ↗
1099
Total Activities
1080
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL4101) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1099 6.31 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.10
CHEMBL1980407 — — 1 8.90
CHEMBL1870106 — — 1 8.50
CHEMBL1994438 — — 1 8.50
CHEMBL2000271 — — 1 8.40
CHEMBL1983315 — — 1 8.40
CHEMBL1968930 — — 1 8.40
CHEMBL1976240 — — 1 8.30
CHEMBL1970903 — — 1 8.30
CHEMBL1972339 — — 1 8.20
CHEMBL2000029 — — 1 8.10
CHEMBL1973720 — — 2 8.10
CHEMBL1998432 — — 1 8.00
CHEMBL1966524 — — 1 8.00
CHEMBL1983945 — — 1 7.90
CHEMBL1996980 — — 1 7.90
CHEMBL1999279 — — 1 7.90
CHEMBL1987756 — — 1 7.90
CHEMBL2001751 — — 1 7.90
CHEMBL1965845 — — 1 7.90
CHEMBL1975121 — — 2 7.90
CHEMBL1979554 — — 1 7.80
CHEMBL1972290 — — 1 7.80
CHEMBL1994669 — — 1 7.80
CHEMBL1965702 — — 1 7.70
CHEMBL1985723 — — 1 7.70
CHEMBL2007574 — — 1 7.70
CHEMBL1991180 — — 1 7.70
CHEMBL1969588 — — 1 7.70
CHEMBL2002726 — — 1 7.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.7943 nM 9.10
CHEMBL1980407 — Ki = 1.259 nM 8.90
CHEMBL1870106 — Ki = 3.162 nM 8.50
CHEMBL1994438 — Ki = 3.162 nM 8.50
CHEMBL2000271 — Ki = 3.981 nM 8.40
CHEMBL1968930 — Ki = 3.981 nM 8.40
CHEMBL1983315 — Ki = 3.981 nM 8.40
CHEMBL1976240 — Ki = 5.012 nM 8.30
CHEMBL1970903 — Ki = 5.012 nM 8.30
CHEMBL1972339 — Ki = 6.31 nM 8.20
CHEMBL1973720 — Ki = 7.943 nM 8.10
CHEMBL1973720 — Ki = 7.943 nM 8.10
CHEMBL2000029 — Ki = 7.943 nM 8.10
CHEMBL1998432 — Ki = 10.0 nM 8.00
CHEMBL1966524 — Ki = 10.0 nM 8.00
CHEMBL1975121 — Ki = 12.59 nM 7.90
CHEMBL1983945 — Ki = 12.59 nM 7.90
CHEMBL1965845 — Ki = 12.59 nM 7.90
CHEMBL2001751 — Ki = 12.59 nM 7.90
CHEMBL1987756 — Ki = 12.59 nM 7.90
CHEMBL1996980 — Ki = 12.59 nM 7.90
CHEMBL1999279 — Ki = 12.59 nM 7.90
CHEMBL1979554 — Ki = 15.85 nM 7.80
CHEMBL1994669 — Ki = 15.85 nM 7.80
CHEMBL1972290 — Ki = 15.85 nM 7.80
CHEMBL1965702 — Ki = 19.95 nM 7.70
CHEMBL2002726 — Ki = 19.95 nM 7.70
CHEMBL1985723 — Ki = 19.95 nM 7.70
CHEMBL2007574 — Ki = 19.95 nM 7.70
CHEMBL1991180 — Ki = 19.95 nM 7.70
CHEMBL1969588 — Ki = 19.95 nM 7.70
CHEMBL1992220 — Ki = 25.12 nM 7.60
CHEMBL1982271 — Ki = 25.12 nM 7.60
CHEMBL1969151 — Ki = 25.12 nM 7.60
CHEMBL1995813 — Ki = 25.12 nM 7.60
CHEMBL1974288 — Ki = 25.12 nM 7.60
CHEMBL1970217 — Ki = 25.12 nM 7.60
CHEMBL1984548 — Ki = 25.12 nM 7.60
CHEMBL1996510 — Ki = 31.62 nM 7.50
CHEMBL2005509 — Ki = 31.62 nM 7.50
CHEMBL1969473 — Ki = 31.62 nM 7.50
CHEMBL1974935 — Ki = 31.62 nM 7.50
CHEMBL1967662 — Ki = 31.62 nM 7.50
CHEMBL1986143 — Ki = 31.62 nM 7.50
CHEMBL1986943 — Ki = 31.62 nM 7.50
CHEMBL220241 GSK-269962A Ki = 31.62 nM 7.50
CHEMBL1986943 — Ki = 31.62 nM 7.50
CHEMBL592030 — Ki = 39.81 nM 7.40
CHEMBL1995712 — Ki = 39.81 nM 7.40
CHEMBL2006299 — Ki = 39.81 nM 7.40