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Assay Detail

CHEMBL1963795

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MINK
ChEMBL ↗
658
Total Activities
647
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Misshapen-like kinase 1 (CHEMBL5518) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 658 6.13 8.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL379975 — — 1 8.90
CHEMBL1986943 — — 2 8.50
CHEMBL1998159 — — 1 8.40
CHEMBL1991674 — — 1 8.40
CHEMBL1996980 — — 1 8.30
CHEMBL1976936 — — 1 8.20
CHEMBL1992220 — — 1 8.20
CHEMBL1997846 — — 1 8.20
CHEMBL2005509 — — 1 8.20
CHEMBL565612 SOTRASTAURIN 2.0 1 8.10
CHEMBL2006439 — — 1 8.10
CHEMBL1986855 — — 1 8.10
CHEMBL522892 DOVITINIB 3.0 1 8.00
CHEMBL1982271 — — 1 8.00
CHEMBL2005718 — — 1 7.90
CHEMBL2005216 — — 1 7.90
CHEMBL1983589 — — 1 7.90
CHEMBL1980253 — — 1 7.80
CHEMBL1994669 — — 1 7.80
CHEMBL1998432 — — 1 7.70
CHEMBL1970903 — — 1 7.70
CHEMBL1973720 — — 2 7.70
CHEMBL1991063 — — 1 7.70
CHEMBL1970142 — — 1 7.60
CHEMBL2006778 — — 1 7.60
CHEMBL1967116 — — 1 7.60
CHEMBL1974870 — — 1 7.60
CHEMBL1984548 — — 1 7.50
CHEMBL49120 PD-0166285 1.0 1 7.50
CHEMBL1969151 — — 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL379975 — Ki = 1.259 nM 8.90
CHEMBL1986943 — Ki = 3.162 nM 8.50
CHEMBL1986943 — Ki = 3.162 nM 8.50
CHEMBL1998159 — Ki = 3.981 nM 8.40
CHEMBL1991674 — Ki = 3.981 nM 8.40
CHEMBL1996980 — Ki = 5.012 nM 8.30
CHEMBL1976936 — Ki = 6.31 nM 8.20
CHEMBL1992220 — Ki = 6.31 nM 8.20
CHEMBL1997846 — Ki = 6.31 nM 8.20
CHEMBL2005509 — Ki = 6.31 nM 8.20
CHEMBL1986855 — Ki = 7.943 nM 8.10
CHEMBL565612 SOTRASTAURIN Ki = 7.943 nM 8.10
CHEMBL2006439 — Ki = 7.943 nM 8.10
CHEMBL1982271 — Ki = 10.0 nM 8.00
CHEMBL522892 DOVITINIB Ki = 10.0 nM 8.00
CHEMBL2005718 — Ki = 12.59 nM 7.90
CHEMBL2005216 — Ki = 12.59 nM 7.90
CHEMBL1983589 — Ki = 12.59 nM 7.90
CHEMBL1980253 — Ki = 15.85 nM 7.80
CHEMBL1994669 — Ki = 15.85 nM 7.80
CHEMBL1973720 — Ki = 19.95 nM 7.70
CHEMBL1973720 — Ki = 19.95 nM 7.70
CHEMBL1970903 — Ki = 19.95 nM 7.70
CHEMBL1998432 — Ki = 19.95 nM 7.70
CHEMBL1991063 — Ki = 19.95 nM 7.70
CHEMBL1967116 — Ki = 25.12 nM 7.60
CHEMBL1974870 — Ki = 25.12 nM 7.60
CHEMBL2006778 — Ki = 25.12 nM 7.60
CHEMBL1970142 — Ki = 25.12 nM 7.60
CHEMBL49120 PD-0166285 Ki = 31.62 nM 7.50
CHEMBL1984548 — Ki = 31.62 nM 7.50
CHEMBL1969151 — Ki = 31.62 nM 7.50
CHEMBL2001751 — Ki = 39.81 nM 7.40
CHEMBL1967878 CENISERTIB Ki = 39.81 nM 7.40
CHEMBL1980562 — Ki = 39.81 nM 7.40
CHEMBL1992634 — Ki = 39.81 nM 7.40
CHEMBL1980297 ILORASERTIB Ki = 50.12 nM 7.30
CHEMBL2002726 — Ki = 50.12 nM 7.30
CHEMBL1997129 — Ki = 63.1 nM 7.20
CHEMBL1993661 — Ki = 63.1 nM 7.20
CHEMBL1985723 — Ki = 63.1 nM 7.20
CHEMBL1996048 — Ki = 63.1 nM 7.20
CHEMBL1965836 — Ki = 63.1 nM 7.20
CHEMBL1992363 — Ki = 79.43 nM 7.10
CHEMBL1980178 — Ki = 79.43 nM 7.10
CHEMBL50894 ALSTERPAULLONE Ki = 79.43 nM 7.10
CHEMBL1990885 — Ki = 79.43 nM 7.10
CHEMBL1997822 — Ki = 79.43 nM 7.10
CHEMBL1998470 — Ki = 100.0 nM 7.00
CHEMBL1972849 — Ki = 100.0 nM 7.00