| Mitogen-activated protein kinase kinase kinase kinase 4 CHEMBL6166 | Ki | 8.1 | 8.1 | 7.9 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 2 CHEMBL5330 | Ki | 7.7 | 7.7 | 19.9 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | Ki | 7.6 | 7.6 | 25.1 | 1 |
| Misshapen-like kinase 1 CHEMBL5518 | Ki | 7.4 | 7.4 | 39.8 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | Ki | 7.3 | 7.3 | 50.1 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 5 CHEMBL4852 | Ki | 7.3 | 7.3 | 50.1 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Tyrosine-protein kinase Fer CHEMBL3982 | Ki | 6.9 | 6.9 | 125.9 | 1 |
| Aurora kinase B CHEMBL2185 | Ki | 6.8 | 6.8 | 158.5 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | Ki | 6.8 | 6.8 | 158.5 | 1 |
| STE20-like serine/threonine-protein kinase CHEMBL4202 | Ki | 6.8 | 6.8 | 158.5 | 1 |
| Tyrosine-protein kinase ITK/TSK CHEMBL2959 | Ki | 6.7 | 6.7 | 199.5 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Serine/threonine-protein kinase 3 CHEMBL4708 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Cyclin-dependent kinase 5 CHEMBL4036 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Cyclin-dependent kinase 2 CHEMBL301 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Phosphorylase b kinase gamma catalytic chain, liver/testis isoform CHEMBL2349 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit delta CHEMBL2801 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Interleukin-1 receptor-associated kinase 1 CHEMBL3357 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Aurora kinase A CHEMBL4722 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit gamma CHEMBL3829 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Homeodomain-interacting protein kinase 4 CHEMBL1075167 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| MAP/microtubule affinity-regulating kinase 3 CHEMBL5600 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Cyclin-dependent kinase 1 CHEMBL308 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Interleukin-1 receptor-associated kinase 4 CHEMBL3778 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Serine/threonine-protein kinase 17A CHEMBL4525 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Dual specificity protein kinase CLK2 CHEMBL4225 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit beta CHEMBL4121 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| Serine/threonine-protein kinase D2 CHEMBL4900 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| Serine/threonine-protein kinase D3 CHEMBL2595 | Ki | 6.3 | 6.3 | 501.2 | 1 |
| Mitogen-activated protein kinase kinase kinase 20 CHEMBL3886 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Serine/threonine-protein kinase Nek4 CHEMBL5819 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Proto-oncogene tyrosine-protein kinase ROS CHEMBL5568 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Tyrosine-protein kinase Fes/Fps CHEMBL5455 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Insulin receptor CHEMBL1981 | Ki | 6.2 | 6.2 | 631.0 | 1 |
| Tyrosine-protein kinase SYK CHEMBL2599 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| Serine/threonine-protein kinase MARK2 CHEMBL3831 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| Casein kinase II subunit alpha CHEMBL3629 | Ki | 6.1 | 6.1 | 794.3 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Serine/threonine-protein kinase N2 CHEMBL3032 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Homeodomain-interacting protein kinase 2 CHEMBL4576 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Lymphokine-activated killer T-cell-originated protein kinase CHEMBL4896 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Serine/threonine-protein kinase TAO1 CHEMBL5261 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Serine/threonine-protein kinase PLK4 CHEMBL3788 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Insulin-like growth factor 1 receptor CHEMBL1957 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Serine/threonine-protein kinase Sgk2 CHEMBL5794 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Mitogen-activated protein kinase 8 CHEMBL2276 | Ki | 5.7 | 5.7 | 1995.3 | 1 |