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Assay Detail

CHEMBL1963790

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK5
ChEMBL ↗
1038
Total Activities
1017
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 5 (CHEMBL4036) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1038 6.21 9.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2006674 — — 1 9.50
CHEMBL191003 JNJ-7706621 — 1 9.30
CHEMBL1980407 — — 1 9.20
CHEMBL1968930 — — 1 8.90
CHEMBL1987448 — — 1 8.70
CHEMBL1973720 — — 2 8.50
CHEMBL1980995 — — 1 8.40
CHEMBL1969588 — — 1 8.30
CHEMBL1990162 — — 1 8.30
CHEMBL1992220 — — 1 8.20
CHEMBL1966204 — — 1 8.20
CHEMBL2007574 — — 1 8.20
CHEMBL1992371 — — 1 8.20
CHEMBL1977223 — — 1 8.20
CHEMBL1996980 — — 1 8.20
CHEMBL2005509 — — 1 8.20
CHEMBL2002649 — — 1 8.10
CHEMBL2000029 — — 1 8.10
CHEMBL1965169 — — 1 8.10
CHEMBL1987034 — — 1 8.10
CHEMBL1999484 — — 1 8.10
CHEMBL1986943 — — 2 8.00
CHEMBL1995811 — — 1 8.00
CHEMBL1999931 — — 1 8.00
CHEMBL1996702 — — 1 8.00
CHEMBL1969151 — — 1 8.00
CHEMBL1983111 — — 1 7.90
CHEMBL50894 ALSTERPAULLONE — 1 7.90
CHEMBL1982271 — — 1 7.90
CHEMBL1991063 — — 1 7.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2006674 — Ki = 0.3162 nM 9.50
CHEMBL191003 JNJ-7706621 Ki = 0.5012 nM 9.30
CHEMBL1980407 — Ki = 0.631 nM 9.20
CHEMBL1968930 — Ki = 1.259 nM 8.90
CHEMBL1987448 — Ki = 1.995 nM 8.70
CHEMBL1973720 — Ki = 3.162 nM 8.50
CHEMBL1973720 — Ki = 3.162 nM 8.50
CHEMBL1980995 — Ki = 3.981 nM 8.40
CHEMBL1969588 — Ki = 5.012 nM 8.30
CHEMBL1990162 — Ki = 5.012 nM 8.30
CHEMBL2007574 — Ki = 6.31 nM 8.20
CHEMBL2005509 — Ki = 6.31 nM 8.20
CHEMBL1996980 — Ki = 6.31 nM 8.20
CHEMBL1992371 — Ki = 6.31 nM 8.20
CHEMBL1992220 — Ki = 6.31 nM 8.20
CHEMBL1966204 — Ki = 6.31 nM 8.20
CHEMBL1977223 — Ki = 6.31 nM 8.20
CHEMBL1999484 — Ki = 7.943 nM 8.10
CHEMBL1965169 — Ki = 7.943 nM 8.10
CHEMBL1987034 — Ki = 7.943 nM 8.10
CHEMBL2002649 — Ki = 7.943 nM 8.10
CHEMBL2000029 — Ki = 7.943 nM 8.10
CHEMBL1996702 — Ki = 10.0 nM 8.00
CHEMBL1986943 — Ki = 10.0 nM 8.00
CHEMBL1986943 — Ki = 10.0 nM 8.00
CHEMBL1999931 — Ki = 10.0 nM 8.00
CHEMBL1969151 — Ki = 10.0 nM 8.00
CHEMBL1995811 — Ki = 10.0 nM 8.00
CHEMBL1986263 — Ki = 12.59 nM 7.90
CHEMBL1974870 — Ki = 12.59 nM 7.90
CHEMBL1982271 — Ki = 12.59 nM 7.90
CHEMBL1977138 — Ki = 12.59 nM 7.90
CHEMBL2003638 — Ki = 12.59 nM 7.90
CHEMBL50894 ALSTERPAULLONE Ki = 12.59 nM 7.90
CHEMBL1991078 — Ki = 12.59 nM 7.90
CHEMBL1977128 — Ki = 12.59 nM 7.90
CHEMBL1974870 — Ki = 12.59 nM 7.90
CHEMBL1983111 — Ki = 12.59 nM 7.90
CHEMBL1991063 — Ki = 12.59 nM 7.90
CHEMBL1994438 — Ki = 12.59 nM 7.90
CHEMBL550418 — Ki = 15.85 nM 7.80
CHEMBL302449 GO-6976 Ki = 15.85 nM 7.80
CHEMBL1084546 PF-00562271 Ki = 15.85 nM 7.80
CHEMBL1983348 — Ki = 19.95 nM 7.70
CHEMBL1989043 — Ki = 19.95 nM 7.70
CHEMBL1987073 — Ki = 19.95 nM 7.70
CHEMBL1965836 — Ki = 19.95 nM 7.70
CHEMBL1995740 — Ki = 19.95 nM 7.70
CHEMBL2000832 — Ki = 25.12 nM 7.60
CHEMBL422897 — Ki = 25.12 nM 7.60