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Target Snapshot

CHEMBL3829 Target Snapshot

Calcium/calmodulin-dependent protein kinase type II subunit gamma · SINGLE PROTEIN · Homo sapiens

1,379Compounds
258Assays
15Approved Drugs
1,011.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q13555. Use UniProt Q13555 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q13555 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calcium/calmodulin-dependent protein kinase type II subunit gamma as ChEMBL target CHEMBL3829, mapped to UniProt Q13555. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calcium/calmodulin-dependent protein kinase type II subunit gamma
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3829
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q13555
Calcium/calmodulin-dependent protein kinase type II subunit gamma
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calcium/calmodulin-dependent protein kinase type II subunit gamma is the right protein anchor across sources, using UniProt Q13555 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalcium/calmodulin-dependent protein kinase type II subunit gamma
UniProt AccessionQ13555
Component TypeProtein
Sequence Length558 aa

Calcium/calmodulin-dependent protein kinase type II subunit gamma

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Calcium/calmodulin-dependent protein kinase type II subunit gamma, mapped to UniProt Q13555. Sequence length is 558 aa.

Mapped IDQ13555
Review nameCalcium/calmodulin-dependent protein kinase type II subunit gamma
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

15
Approved
6
Phase III
12
Phase II
8
Phase I
Assay Mix

Activity Type Distribution

IC5025.0
KI592.0
KD394.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL388978 9.44 IC50 0.366 Preclinical
CHEMBL388978 9.3 Kd 0.5 Preclinical
CHEMBL3683258 9.15 IC50 0.7 Preclinical
CHEMBL4556306 9.1 IC50 0.79 Preclinical
CHEMBL1966628 8.4 Ki 3.981 Preclinical
CHEMBL1974870 8.4 Ki 3.981 Preclinical
CHEMBL4465866 8.1 Kd 8.0 Preclinical
CHEMBL4576489 8.05 Kd 9.0 Preclinical
CHEMBL1998159 8.0 Ki 10.0 Preclinical
CHEMBL5653589 7.95 Kd 11.22 Preclinical
Distribution

pChEMBL Value Distribution

71
5.0
98
5.5
52
6.0
27
6.5
13
7.0
11
7.5
6
8.0
0
8.5
8
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MOMELOTINIB
CHEMBL1078178
Approved 2023
FEDRATINIB
CHEMBL1287853
Approved 2019
GILTERITINIB
CHEMBL3301622
Approved 2018
ABEMACICLIB
CHEMBL3301610
Approved 2017
BRIGATINIB
CHEMBL3545311
Approved 2017
MIDOSTAURIN
CHEMBL608533
Approved 2017
BARICITINIB
CHEMBL2105759
Approved 2017
RIBOCICLIB
CHEMBL3545110
Approved 2017
BOSUTINIB
CHEMBL288441
Approved 2012
RUXOLITINIB
CHEMBL1789941
Approved 2011
SUNITINIB
CHEMBL535
Approved 2006
Assay Landscape

Assay Landscape

258
Total Assays
213
Tested Compounds
2
Assay Types
Binding — 257 assays, 51 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 157 32 6.7
cell-based format 36 2 8.1
subcellular format 33 17 6.3
assay format 31 0
Functional — 1 assays, 213 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 213 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine