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Assay Detail

CHEMBL1963747

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ITK
ChEMBL ↗
606
Total Activities
600
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase ITK/TSK (CHEMBL2959) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 606 6.72 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1993661 — — 1 8.50
CHEMBL1987034 — — 1 8.40
CHEMBL1983111 — — 1 8.40
CHEMBL1989708 — — 1 8.40
CHEMBL509032 TAE-684 — 1 8.30
CHEMBL1979516 — — 1 8.30
CHEMBL1980995 — — 1 8.10
CHEMBL485556 — — 1 8.00
CHEMBL1980297 ILORASERTIB 2.0 1 7.90
CHEMBL1970142 — — 1 7.80
CHEMBL508928 — — 1 7.80
CHEMBL1970317 — — 1 7.80
CHEMBL1241473 — — 1 7.80
CHEMBL1970104 — — 2 7.70
CHEMBL1997617 — — 1 7.60
CHEMBL1967878 CENISERTIB 2.0 1 7.60
CHEMBL302449 GO-6976 — 1 7.60
CHEMBL1990885 — — 1 7.60
CHEMBL1967116 — — 1 7.60
CHEMBL1982476 — — 1 7.50
CHEMBL2004716 — — 1 7.50
CHEMBL1988387 — — 1 7.40
CHEMBL1969102 — — 1 7.40
CHEMBL1988838 — — 1 7.40
CHEMBL522892 DOVITINIB 3.0 1 7.30
CHEMBL1982466 — — 1 7.30
CHEMBL2005631 — — 1 7.30
CHEMBL572878 TOZASERTIB 2.0 1 7.20
CHEMBL1971029 — — 1 7.20
CHEMBL1970083 — — 1 7.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1993661 — Ki = 3.162 nM 8.50
CHEMBL1987034 — Ki = 3.981 nM 8.40
CHEMBL1983111 — Ki = 3.981 nM 8.40
CHEMBL1989708 — Ki = 3.981 nM 8.40
CHEMBL1979516 — Ki = 5.012 nM 8.30
CHEMBL509032 TAE-684 Ki = 5.012 nM 8.30
CHEMBL1980995 — Ki = 7.943 nM 8.10
CHEMBL485556 — Ki = 10.0 nM 8.00
CHEMBL1980297 ILORASERTIB Ki = 12.59 nM 7.90
CHEMBL508928 — Ki = 15.85 nM 7.80
CHEMBL1970317 — Ki = 15.85 nM 7.80
CHEMBL1241473 — Ki = 15.85 nM 7.80
CHEMBL1970142 — Ki = 15.85 nM 7.80
CHEMBL1970104 — Ki = 19.95 nM 7.70
CHEMBL1970104 — Ki = 19.95 nM 7.70
CHEMBL1997617 — Ki = 25.12 nM 7.60
CHEMBL1967116 — Ki = 25.12 nM 7.60
CHEMBL302449 GO-6976 Ki = 25.12 nM 7.60
CHEMBL1990885 — Ki = 25.12 nM 7.60
CHEMBL1967878 CENISERTIB Ki = 25.12 nM 7.60
CHEMBL1982476 — Ki = 31.62 nM 7.50
CHEMBL2004716 — Ki = 31.62 nM 7.50
CHEMBL1988387 — Ki = 39.81 nM 7.40
CHEMBL1969102 — Ki = 39.81 nM 7.40
CHEMBL1988838 — Ki = 39.81 nM 7.40
CHEMBL522892 DOVITINIB Ki = 50.12 nM 7.30
CHEMBL1982466 — Ki = 50.12 nM 7.30
CHEMBL2005631 — Ki = 50.12 nM 7.30
CHEMBL1970083 — Ki = 63.1 nM 7.20
CHEMBL1971029 — Ki = 63.1 nM 7.20
CHEMBL572878 TOZASERTIB Ki = 63.1 nM 7.20
CHEMBL1084546 PF-00562271 Ki = 79.43 nM 7.10
CHEMBL1988717 — Ki = 79.43 nM 7.10
CHEMBL475251 R-406 Ki = 79.43 nM 7.10
CHEMBL2005886 — Ki = 100.0 nM 7.00
CHEMBL2001485 — Ki = 100.0 nM 7.00
CHEMBL1988163 — Ki = 100.0 nM 7.00
CHEMBL1982465 — Ki = 100.0 nM 7.00
CHEMBL1980391 RG-1530 Ki = 125.89 nM 6.90
CHEMBL1973540 — Ki = 125.89 nM 6.90
CHEMBL1997623 — Ki = 125.89 nM 6.90
CHEMBL484390 — Ki = 158.49 nM 6.80
CHEMBL1982957 — Ki = 158.49 nM 6.80
CHEMBL1984711 — Ki = 158.49 nM 6.80
CHEMBL1983923 — Ki = 158.49 nM 6.80
CHEMBL1992634 — Ki = 199.53 nM 6.70
CHEMBL1978099 — Ki = 199.53 nM 6.70
CHEMBL1976420 — Ki = 199.53 nM 6.70
CHEMBL1981047 — Ki = 199.53 nM 6.70
CHEMBL519697 — Ki = 199.53 nM 6.70