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Assay Detail

CHEMBL1963772

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K2
ChEMBL ↗
909
Total Activities
892
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase kinase kinase kinase 2 (CHEMBL5330) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 909 6.15 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1994669 — — 1 8.70
CHEMBL244378 — — 1 8.50
CHEMBL1984548 — — 1 8.50
CHEMBL1997129 — — 1 8.30
CHEMBL1980995 — — 1 8.30
CHEMBL1967878 CENISERTIB 2.0 1 8.30
CHEMBL396523 — — 1 8.30
CHEMBL1241473 — — 1 8.10
CHEMBL1973540 — — 1 8.10
CHEMBL1991674 — — 1 8.10
CHEMBL1980297 ILORASERTIB 2.0 1 8.10
CHEMBL1971029 — — 1 8.00
CHEMBL1970142 — — 1 7.90
CHEMBL1983575 — — 1 7.90
CHEMBL1988163 — — 1 7.80
CHEMBL1986855 — — 1 7.80
CHEMBL1190711 — — 1 7.80
CHEMBL1980407 — — 1 7.80
CHEMBL1986263 — — 1 7.70
CHEMBL1974328 — — 1 7.70
CHEMBL1972220 — — 1 7.70
CHEMBL1992634 — — 1 7.70
CHEMBL1982466 — — 1 7.70
CHEMBL243088 — — 1 7.70
CHEMBL1970903 — — 1 7.60
CHEMBL1972142 — — 1 7.60
CHEMBL1997822 — — 1 7.60
CHEMBL1988387 — — 1 7.50
CHEMBL1967116 — — 1 7.50
CHEMBL1994438 — — 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1994669 — Ki = 1.995 nM 8.70
CHEMBL1984548 — Ki = 3.162 nM 8.50
CHEMBL244378 — Ki = 3.162 nM 8.50
CHEMBL1997129 — Ki = 5.012 nM 8.30
CHEMBL1967878 CENISERTIB Ki = 5.012 nM 8.30
CHEMBL396523 — Ki = 5.012 nM 8.30
CHEMBL1980995 — Ki = 5.012 nM 8.30
CHEMBL1980297 ILORASERTIB Ki = 7.943 nM 8.10
CHEMBL1991674 — Ki = 7.943 nM 8.10
CHEMBL1241473 — Ki = 7.943 nM 8.10
CHEMBL1973540 — Ki = 7.943 nM 8.10
CHEMBL1971029 — Ki = 10.0 nM 8.00
CHEMBL1970142 — Ki = 12.59 nM 7.90
CHEMBL1983575 — Ki = 12.59 nM 7.90
CHEMBL1986855 — Ki = 15.85 nM 7.80
CHEMBL1190711 — Ki = 15.85 nM 7.80
CHEMBL1980407 — Ki = 15.85 nM 7.80
CHEMBL1988163 — Ki = 15.85 nM 7.80
CHEMBL243088 — Ki = 19.95 nM 7.70
CHEMBL1972220 — Ki = 19.95 nM 7.70
CHEMBL1992634 — Ki = 19.95 nM 7.70
CHEMBL1986263 — Ki = 19.95 nM 7.70
CHEMBL1982466 — Ki = 19.95 nM 7.70
CHEMBL1974328 — Ki = 19.95 nM 7.70
CHEMBL1972142 — Ki = 25.12 nM 7.60
CHEMBL1970903 — Ki = 25.12 nM 7.60
CHEMBL1997822 — Ki = 25.12 nM 7.60
CHEMBL1967116 — Ki = 31.62 nM 7.50
CHEMBL1980329 — Ki = 31.62 nM 7.50
CHEMBL1988387 — Ki = 31.62 nM 7.50
CHEMBL1994438 — Ki = 31.62 nM 7.50
CHEMBL1970104 — Ki = 39.81 nM 7.40
CHEMBL1983111 — Ki = 39.81 nM 7.40
CHEMBL1992363 — Ki = 39.81 nM 7.40
CHEMBL2004716 — Ki = 39.81 nM 7.40
CHEMBL1993904 — Ki = 39.81 nM 7.40
CHEMBL1965507 — Ki = 39.81 nM 7.40
CHEMBL1970104 — Ki = 39.81 nM 7.40
CHEMBL2001751 — Ki = 39.81 nM 7.40
CHEMBL1986943 — Ki = 39.81 nM 7.40
CHEMBL1986943 — Ki = 39.81 nM 7.40
CHEMBL1997534 — Ki = 39.81 nM 7.40
CHEMBL2005216 — Ki = 39.81 nM 7.40
CHEMBL1879463 DACTOLISIB Ki = 50.12 nM 7.30
CHEMBL1996980 — Ki = 50.12 nM 7.30
CHEMBL2005509 — Ki = 50.12 nM 7.30
CHEMBL1968930 — Ki = 50.12 nM 7.30
CHEMBL1992220 — Ki = 50.12 nM 7.30
CHEMBL1974310 — Ki = 50.12 nM 7.30
CHEMBL1725279 SP-600125 Ki = 50.12 nM 7.30