Serine/threonine-protein kinase Nek4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P51957. Use UniProt P51957 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P51957 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase Nek4
Review this target as Serine/threonine-protein kinase Nek4, mapped to UniProt P51957. Sequence length is 841 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase Nek4 as ChEMBL target CHEMBL5819, mapped to UniProt P51957. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase Nek4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P51957 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase Nek4 |
| UniProt Accession | P51957 |
| Component Type | Protein |
| Sequence Length | 841 aa |
Serine/threonine-protein kinase Nek4
Review this target as Serine/threonine-protein kinase Nek4, mapped to UniProt P51957. Sequence length is 841 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1997129 | 8.3 | Ki | 5.012 | Preclinical |
| CHEMBL1241473 | 8.2 | Ki | 6.31 | Preclinical |
| CHEMBL1987034 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL396523 | 7.9 | Ki | 12.59 | Preclinical |
| CHEMBL244378 | 7.9 | Ki | 12.59 | Preclinical |
| CHEMBL1993661 | 7.8 | Ki | 15.85 | Preclinical |
| CHEMBL1190711 | 7.6 | Ki | 25.12 | Preclinical |
| CHEMBL243088 | 7.4 | Ki | 39.81 | Preclinical |
| CHEMBL4568087 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL388978 | 7.31 | IC50 | 49.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 126 | 13 | 6.4 |
| assay format | 25 | 5 | 6.4 |
| cell-based format | 14 | 0 | — |
| subcellular format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 180 | 5.9 |