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Assay Detail

CHEMBL1963741

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1A1
ChEMBL ↗
939
Total Activities
921
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Casein kinase I isoform alpha (CHEMBL2793) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 939 5.83 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1993904 — — 1 8.10
CHEMBL1965660 — — 2 8.10
CHEMBL1997335 — — 1 7.90
CHEMBL274064 SB-220025 — 1 7.90
CHEMBL1981079 — — 1 7.80
CHEMBL1973720 — — 2 7.80
CHEMBL225519 — — 1 7.50
CHEMBL1983575 — — 1 7.50
CHEMBL1996980 — — 1 7.40
CHEMBL1985681 — — 1 7.40
CHEMBL1081312 — — 1 7.40
CHEMBL1966628 — — 1 7.30
CHEMBL1997129 — — 1 7.30
CHEMBL1982700 — — 1 7.30
CHEMBL1993877 — — 1 7.30
CHEMBL1986943 — — 2 7.20
CHEMBL1983715 — — 1 7.20
CHEMBL2000508 — — 1 7.10
CHEMBL1982271 — — 1 7.10
CHEMBL1999484 — — 1 7.10
CHEMBL1964290 — — 1 7.00
CHEMBL363648 TAK-715 2.0 1 7.00
CHEMBL1994669 — — 1 7.00
CHEMBL243298 — — 1 7.00
CHEMBL440084 SB-431542 — 1 7.00
CHEMBL1971186 — — 1 6.90
CHEMBL1988581 — — 1 6.90
CHEMBL1974870 — — 1 6.90
CHEMBL1973359 — — 1 6.90
CHEMBL2006456 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1993904 — Ki = 7.943 nM 8.10
CHEMBL1965660 — Ki = 7.943 nM 8.10
CHEMBL1965660 — Ki = 7.943 nM 8.10
CHEMBL274064 SB-220025 Ki = 12.59 nM 7.90
CHEMBL1997335 — Ki = 12.59 nM 7.90
CHEMBL1973720 — Ki = 15.85 nM 7.80
CHEMBL1973720 — Ki = 15.85 nM 7.80
CHEMBL1981079 — Ki = 15.85 nM 7.80
CHEMBL225519 — Ki = 31.62 nM 7.50
CHEMBL1983575 — Ki = 31.62 nM 7.50
CHEMBL1985681 — Ki = 39.81 nM 7.40
CHEMBL1081312 — Ki = 39.81 nM 7.40
CHEMBL1996980 — Ki = 39.81 nM 7.40
CHEMBL1966628 — Ki = 50.12 nM 7.30
CHEMBL1997129 — Ki = 50.12 nM 7.30
CHEMBL1982700 — Ki = 50.12 nM 7.30
CHEMBL1993877 — Ki = 50.12 nM 7.30
CHEMBL1983715 — Ki = 63.1 nM 7.20
CHEMBL1986943 — Ki = 63.1 nM 7.20
CHEMBL1986943 — Ki = 63.1 nM 7.20
CHEMBL1982271 — Ki = 79.43 nM 7.10
CHEMBL1999484 — Ki = 79.43 nM 7.10
CHEMBL2000508 — Ki = 79.43 nM 7.10
CHEMBL363648 TAK-715 Ki = 100.0 nM 7.00
CHEMBL440084 SB-431542 Ki = 100.0 nM 7.00
CHEMBL1994669 — Ki = 100.0 nM 7.00
CHEMBL1964290 — Ki = 100.0 nM 7.00
CHEMBL243298 — Ki = 100.0 nM 7.00
CHEMBL1988581 — Ki = 125.89 nM 6.90
CHEMBL1971186 — Ki = 125.89 nM 6.90
CHEMBL1974870 — Ki = 125.89 nM 6.90
CHEMBL1973359 — Ki = 125.89 nM 6.90
CHEMBL1966204 — Ki = 158.49 nM 6.80
CHEMBL2006456 — Ki = 158.49 nM 6.80
CHEMBL1990904 — Ki = 158.49 nM 6.80
CHEMBL1996791 — Ki = 158.49 nM 6.80
CHEMBL1998432 — Ki = 199.53 nM 6.70
CHEMBL1982383 — Ki = 199.53 nM 6.70
CHEMBL2005792 — Ki = 199.53 nM 6.70
CHEMBL1969588 — Ki = 199.53 nM 6.70
CHEMBL1984548 — Ki = 199.53 nM 6.70
CHEMBL1983348 — Ki = 199.53 nM 6.70
CHEMBL379975 — Ki = 251.19 nM 6.60
CHEMBL1975212 — Ki = 251.19 nM 6.60
CHEMBL2003638 — Ki = 251.19 nM 6.60
CHEMBL1975490 — Ki = 251.19 nM 6.60
CHEMBL1999931 — Ki = 251.19 nM 6.60
CHEMBL1996176 — Ki = 251.19 nM 6.60
CHEMBL1992371 — Ki = 251.19 nM 6.60
CHEMBL1990162 — Ki = 251.19 nM 6.60