Assay Detail
Binding
CHEMBL735050
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Inhibition against Mitogen-activated protein kinase p38 alpha
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.39 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97550 | — | — | 1 | 8.85 |
| CHEMBL408876 | — | — | 1 | 8.82 |
| CHEMBL318892 | — | — | 1 | 8.52 |
| CHEMBL329049 | — | — | 1 | 8.07 |
| CHEMBL420081 | — | — | 1 | 8.02 |
| CHEMBL329080 | — | — | 1 | 7.92 |
| CHEMBL319716 | — | — | 1 | 7.75 |
| CHEMBL95692 | SB-242235 | — | 1 | 7.72 |
| CHEMBL275798 | — | — | 1 | 7.70 |
| CHEMBL274064 | SB-220025 | — | 1 | 7.70 |
| CHEMBL419149 | — | — | 1 | 7.57 |
| CHEMBL95931 | — | — | 1 | 7.48 |
| CHEMBL97162 | — | — | 1 | 7.47 |
| CHEMBL95521 | — | — | 1 | 7.38 |
| CHEMBL95365 | — | — | 1 | 7.35 |
| CHEMBL95797 | — | — | 1 | 7.28 |
| CHEMBL330422 | — | — | 1 | 7.28 |
| CHEMBL95502 | — | — | 1 | 7.24 |
| CHEMBL327949 | — | — | 1 | 7.10 |
| CHEMBL319988 | — | — | 1 | 7.08 |
| CHEMBL95207 | — | — | 1 | 7.07 |
| CHEMBL329447 | — | — | 1 | 7.00 |
| CHEMBL97604 | — | — | 1 | 6.80 |
| CHEMBL316917 | — | — | 1 | 6.77 |
| CHEMBL95206 | — | — | 1 | 6.77 |
| CHEMBL330196 | — | — | 1 | 6.64 |
| CHEMBL97451 | — | — | 1 | 6.41 |
| CHEMBL274863 | — | — | 1 | 6.32 |
| CHEMBL329469 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97550 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL408876 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL318892 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL329049 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL420081 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL329080 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL319716 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL95692 | SB-242235 | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL275798 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL274064 | SB-220025 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL419149 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL95931 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL97162 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL95521 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL95365 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL95797 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL330422 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL95502 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL327949 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL319988 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL95207 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL329447 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL97604 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL316917 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL95206 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL330196 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL97451 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL274863 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL329469 | — | IC50 | = | 610.0 | nM | 6.21 |