Assay Detail
Binding
CHEMBL4136222
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Inhibition of MAPK p38 (unknown origin)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Intermediate |
Publication
Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.19 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738839 | — | — | 1 | 9.09 |
| CHEMBL1232784 | — | — | 1 | 8.70 |
| CHEMBL258202 | — | — | 1 | 8.46 |
| CHEMBL476351 | GW775608X | — | 1 | 8.22 |
| CHEMBL257341 | — | — | 1 | 8.19 |
| CHEMBL4168810 | — | — | 1 | 8.05 |
| CHEMBL1929215 | — | — | 1 | 7.75 |
| CHEMBL1929238 | — | — | 1 | 7.66 |
| CHEMBL4166018 | — | — | 1 | 7.36 |
| CHEMBL218962 | — | — | 1 | 7.30 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 7.16 |
| CHEMBL1929195 | — | — | 1 | 7.12 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.00 |
| CHEMBL1738943 | — | — | 1 | 6.23 |
| CHEMBL1233784 | — | — | 1 | 5.72 |
| CHEMBL1929210 | — | — | 1 | 5.64 |
| CHEMBL1232634 | — | — | 1 | 5.62 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738839 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL1232784 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL258202 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL476351 | GW775608X | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL257341 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4168810 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1929215 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1929238 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4166018 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL218962 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1929195 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1738943 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL1233784 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1929210 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1232634 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL941 | IMATINIB | IC50 | = | 70000.0 | nM | 4.16 |