Compound Detail
CHEMBL257341
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL257341 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FQYJTHIYAQQJAB-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
5.58
ALogP
5
HBA
1
HBD
51.0
PSA (Ų)
0.52
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase p38 CHEMBL2094115 | IC50 | 8.19 | 8.19 | 6.5 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.19 | 8.19 | 6.4 | 1 |
| PBMC CHEMBL613107 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 6.4 | nM | 8.19 | Inhibition of p38alpha | 18296051 |
| MAP kinase p38 | IC50 | = | 6.5 | nM | 8.19 | Inhibition of MAPK p38 (unknown origin) | 29133046 |
| PBMC | IC50 | = | 40.0 | nM | 7.4 | Inhibition of LPS-induced TNFalpha production in human PBMC | 18296051 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18296051 | 10.1016/j.bmcl.2008.02.011 | Mitogen-activated protein kinase 14 | 1 |
| 18296051 | 10.1016/j.bmcl.2008.02.011 | PBMC | 1 |
| 29133046 | 10.1016/j.ejmech.2017.10.061 | MAP kinase p38 | 1 |
Data from ChEMBL 36 via Core Engine