Assay Detail
Binding
CHEMBL929902
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Inhibition of purified human p38alpha
9
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.58 | 7.75 |
| IC50 | 4 | 5.49 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 7.75 |
| CHEMBL270164 | GW607117X | — | 2 | 6.62 |
| CHEMBL237127 | — | — | 2 | 6.40 |
| CHEMBL273158 | — | — | 2 | 6.32 |
| CHEMBL270608 | — | — | 2 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL270164 | GW607117X | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL237127 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL273158 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL270164 | GW607117X | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL270608 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL237127 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL273158 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL270608 | — | IC50 | = | 10000.0 | nM | 5.00 |