Assay Detail
Functional
CHEMBL929948
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Inhibition of LPS-induced TNFalpha biosynthesis in human PBMC
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.75 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403200 | — | — | 1 | 9.00 |
| CHEMBL255482 | — | — | 1 | 8.57 |
| CHEMBL258202 | — | — | 1 | 8.54 |
| CHEMBL258203 | — | — | 1 | 8.39 |
| CHEMBL258223 | — | — | 1 | 8.19 |
| CHEMBL255288 | — | — | 1 | 8.10 |
| CHEMBL258201 | — | — | 1 | 8.06 |
| CHEMBL255698 | — | — | 1 | 7.96 |
| CHEMBL257994 | — | — | 1 | 7.64 |
| CHEMBL257995 | — | — | 1 | 7.46 |
| CHEMBL257996 | — | — | 1 | 7.38 |
| CHEMBL403141 | — | — | 1 | 6.80 |
| CHEMBL254365 | — | — | 1 | 6.62 |
| CHEMBL258403 | — | — | 1 | 5.82 |
| CHEMBL255254 | — | — | 1 | - |
| CHEMBL258418 | — | — | 1 | - |
| CHEMBL254169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403200 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL255482 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL258202 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL258203 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL258223 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL255288 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL258201 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL255698 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL257994 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL257995 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL257996 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL403141 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL254365 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL258403 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL255254 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL258418 | — | IC50 | > | 250.0 | nM | - |
| CHEMBL254169 | — | IC50 | > | 250.0 | nM | - |