Compound Detail
CHEMBL403200
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Basic Information
| ChEMBL ID | CHEMBL403200 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QGJDHDIEZQDSIA-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
385.4
MW (Da)
3.76
ALogP
7
HBA
3
HBD
109.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PBMC CHEMBL613107 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.42 | 8.42 | 3.8 | 1 |
| Tyrosine-protein kinase Lck CHEMBL258 | IC50 | 6.42 | 6.42 | 380.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.42 | 6.42 | 380.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PBMC | IC50 | = | 1.0 | nM | 9.0 | Inhibition of LPS-induced TNFalpha biosynthesis in human PBMC | 18313298 |
| Mitogen-activated protein kinase 14 | IC50 | = | 3.8 | nM | 8.42 | Inhibition of human p38alpha | 18313298 |
| Tyrosine-protein kinase Lck | IC50 | = | 380.0 | nM | 6.42 | Inhibition of Lck | 18313298 |
| Unchecked | IC50 | = | 380.0 | nM | 6.42 | Selectivity for human p38-alpha over Lck | 18313298 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18313298 | 10.1016/j.bmcl.2008.02.031 | Mitogen-activated protein kinase 14 | 1 |
| 18313298 | 10.1016/j.bmcl.2008.02.031 | PBMC | 1 |
| 18313298 | 10.1016/j.bmcl.2008.02.031 | Tyrosine-protein kinase Lck | 1 |
| 18313298 | 10.1016/j.bmcl.2008.02.031 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine