Assay Detail
Binding
CHEMBL929949
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Inhibition of Lck
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.67 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258403 | — | — | 1 | 6.85 |
| CHEMBL403200 | — | — | 1 | 6.42 |
| CHEMBL255482 | — | — | 1 | 5.72 |
| CHEMBL255428 | — | — | 1 | 5.48 |
| CHEMBL257996 | — | — | 1 | 5.32 |
| CHEMBL258223 | — | — | 1 | 5.24 |
| CHEMBL258202 | — | — | 1 | 4.66 |
| CHEMBL255698 | — | — | 1 | - |
| CHEMBL258203 | — | — | 1 | - |
| CHEMBL258201 | — | — | 1 | - |
| CHEMBL257995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258403 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL403200 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL255482 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL255428 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL257996 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL258223 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL258202 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL255698 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL258203 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL258201 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL257995 | — | IC50 | > | 50000.0 | nM | - |