Assay Detail
Binding
CHEMBL929947
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Inhibition of human p38alpha
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.71 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255482 | — | — | 1 | 8.70 |
| CHEMBL258203 | — | — | 1 | 8.64 |
| CHEMBL257995 | — | — | 1 | 8.49 |
| CHEMBL255698 | — | — | 1 | 8.47 |
| CHEMBL258201 | — | — | 1 | 8.46 |
| CHEMBL258202 | — | — | 1 | 8.46 |
| CHEMBL403200 | — | — | 1 | 8.42 |
| CHEMBL257994 | — | — | 1 | 8.39 |
| CHEMBL255288 | — | — | 1 | 8.38 |
| CHEMBL257996 | — | — | 1 | 8.35 |
| CHEMBL258223 | — | — | 1 | 8.27 |
| CHEMBL403141 | — | — | 1 | 7.89 |
| CHEMBL258418 | — | — | 1 | 7.66 |
| CHEMBL255254 | — | — | 1 | 7.55 |
| CHEMBL254169 | — | — | 1 | 7.47 |
| CHEMBL255428 | — | — | 1 | 7.44 |
| CHEMBL258403 | — | — | 1 | 7.41 |
| CHEMBL254365 | — | — | 1 | 7.28 |
| CHEMBL186177 | — | — | 1 | 7.21 |
| CHEMBL255931 | — | — | 1 | 6.96 |
| CHEMBL258247 | — | — | 1 | 6.96 |
| CHEMBL404446 | — | — | 1 | 6.89 |
| CHEMBL403140 | — | — | 1 | 6.85 |
| CHEMBL254168 | — | — | 1 | 6.80 |
| CHEMBL255719 | — | — | 1 | 6.57 |
| CHEMBL402943 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255482 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL258203 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL257995 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL255698 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL258201 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL258202 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL403200 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL257994 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL255288 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL257996 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL258223 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL403141 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL258418 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL255254 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL254169 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL255428 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL258403 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL254365 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL186177 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL255931 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL258247 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL404446 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL403140 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL254168 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL255719 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL402943 | — | IC50 | = | 330.0 | nM | 6.48 |