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Assay Detail

CHEMBL929975

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at mouse P2Y2 receptor in mouse NG108-15 cells assessed as inhibition of UTP-induced calcium mobilization
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type NG108-15
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 2 (CHEMBL1075298)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.
Weyler S, Baqi Y, Hillmann P, Kaulich M, Hunder AM, Müller IA, Müller CE.
Bioorg Med Chem Lett (2008) 18 : 223 -227
PubMed 18006312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.85 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL223344 RB 2 1 5.30
CHEMBL256688 1 5.05
CHEMBL257495 1 5.05
CHEMBL271881 1 5.05
CHEMBL256864 1 5.00
CHEMBL256057 ACID BLUE 25 1 4.96
CHEMBL271688 1 4.92
CHEMBL402239 1 4.85
CHEMBL256689 1 4.77
CHEMBL401735 1 4.77
CHEMBL403051 1 4.77
CHEMBL271673 1 4.70
CHEMBL445413 1 4.66
CHEMBL402238 1 4.62
CHEMBL404450 1 4.57
CHEMBL401859 1 4.52
CHEMBL271672 1 -
CHEMBL404659 1 -
CHEMBL271689 1 -
CHEMBL270415 BROMAMINIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL223344 RB 2 IC50 = 5000.0 nM 5.30
CHEMBL256688 IC50 = 9000.0 nM 5.05
CHEMBL257495 IC50 = 9000.0 nM 5.05
CHEMBL271881 IC50 = 9000.0 nM 5.05
CHEMBL256864 IC50 = 10000.0 nM 5.00
CHEMBL256057 ACID BLUE 25 IC50 = 11100.0 nM 4.96
CHEMBL271688 IC50 = 12000.0 nM 4.92
CHEMBL402239 IC50 = 14000.0 nM 4.85
CHEMBL256689 IC50 = 17000.0 nM 4.77
CHEMBL401735 IC50 = 17000.0 nM 4.77
CHEMBL403051 IC50 = 17000.0 nM 4.77
CHEMBL271673 IC50 = 20000.0 nM 4.70
CHEMBL445413 IC50 = 22000.0 nM 4.66
CHEMBL402238 IC50 = 24000.0 nM 4.62
CHEMBL404450 IC50 = 27000.0 nM 4.57
CHEMBL401859 IC50 = 30000.0 nM 4.52
CHEMBL271672 IC50 > 100000.0 nM -
CHEMBL404659 IC50 > 100000.0 nM -
CHEMBL271689 IC50 > 100000.0 nM -
CHEMBL270415 BROMAMINIC ACID IC50 > 100000.0 nM -