Compound Detail
CHEMBL270415
BROMAMINIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL270415 |
| Name | BROMAMINIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TXMRAEGWZZVGIH-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1206406 |
| Active Moiety | CHEMBL1206406 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
382.2
MW (Da)
2.05
ALogP
5
HBA
2
HBD
114.5
PSA (Ų)
0.49
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-ketoglutarate-dependent dioxygenase FTO CHEMBL2331065 | IC50 | 4.96 | 4.565 | 11000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-ketoglutarate-dependent dioxygenase FTO | IC50 | = | 11000.0 | nM | 4.96 | Inhibition of human hexahistidine-tagged full-length FTO expressed in Escherichi... | 23547775 |
| Alpha-ketoglutarate-dependent dioxygenase FTO | IC50 | = | 68000.0 | nM | 4.17 | Displacement of ssDNA with ATTGTCA (m6A) CAGCAGA-FAM from human FTO measured aft... | 34792334 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18006312 | 10.1016/j.bmcl.2007.10.082 | P2Y purinoceptor 2 | 2 |
| 23547775 | 10.1021/jm400193d | Alpha-ketoglutarate-dependent dioxygenase FTO | 1 |
| 34792334 | 10.1021/acs.jmedchem.1c01694 | Alpha-ketoglutarate-dependent dioxygenase FTO | 1 |
Data from ChEMBL 36 via Core Engine