Assay Detail
Functional
CHEMBL929976
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Antagonist activity at human recombinant P2Y2 receptor in 1321N1 cells assessed as inhibition of UTP-induced calcium mobilization
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.09 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223344 | RB 2 | — | 1 | 5.73 |
| CHEMBL445413 | — | — | 1 | 5.52 |
| CHEMBL401859 | — | — | 1 | 5.41 |
| CHEMBL271673 | — | — | 1 | 5.28 |
| CHEMBL256688 | — | — | 1 | 5.26 |
| CHEMBL256057 | ACID BLUE 25 | — | 1 | 5.25 |
| CHEMBL271688 | — | — | 1 | 5.24 |
| CHEMBL404659 | — | — | 1 | 5.12 |
| CHEMBL402239 | — | — | 1 | 5.10 |
| CHEMBL402238 | — | — | 1 | 5.03 |
| CHEMBL257495 | — | — | 1 | 5.01 |
| CHEMBL401735 | — | — | 1 | 4.94 |
| CHEMBL271881 | — | — | 1 | 4.94 |
| CHEMBL403051 | — | — | 1 | 4.82 |
| CHEMBL256864 | — | — | 1 | 4.79 |
| CHEMBL404450 | — | — | 1 | 4.60 |
| CHEMBL256689 | — | — | 1 | 4.52 |
| CHEMBL271672 | — | — | 1 | - |
| CHEMBL271689 | — | — | 1 | - |
| CHEMBL270415 | BROMAMINIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223344 | RB 2 | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL445413 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL401859 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL271673 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL256688 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL256057 | ACID BLUE 25 | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL271688 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL404659 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL402239 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL402238 | — | IC50 | = | 9260.0 | nM | 5.03 |
| CHEMBL257495 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL401735 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL271881 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL403051 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL256864 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL404450 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL256689 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL271672 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL271689 | — | IC50 | - | — | - | |
| CHEMBL270415 | BROMAMINIC ACID | IC50 | - | — | - |