Assay Detail
Binding
CHEMBL929986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HTLV1 protease L40I mutant expressed in Escherichia coli BL21(DE3)pLysS
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human T-cell leukemia virus type I |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gag-Pro polyprotein (CHEMBL3346) ↗| Type | SINGLE PROTEIN |
| Organism | Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) |
Publication
Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.82 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272710 | — | — | 1 | 7.08 |
| CHEMBL271706 | — | — | 1 | 7.06 |
| CHEMBL272280 | — | — | 1 | 7.02 |
| CHEMBL271878 | — | — | 1 | 7.00 |
| CHEMBL403182 | — | — | 1 | 6.99 |
| CHEMBL404702 | — | — | 1 | 6.99 |
| CHEMBL403240 | — | — | 1 | 6.97 |
| CHEMBL256022 | — | — | 1 | 6.95 |
| CHEMBL403770 | — | — | 1 | 6.91 |
| CHEMBL256587 | — | — | 1 | 6.88 |
| CHEMBL401718 | — | — | 1 | 6.85 |
| CHEMBL271454 | — | — | 1 | 6.84 |
| CHEMBL272920 | — | — | 1 | 6.84 |
| CHEMBL404836 | — | — | 1 | 6.84 |
| CHEMBL436816 | — | — | 1 | 6.82 |
| CHEMBL257647 | — | — | 1 | 6.80 |
| CHEMBL256385 | — | — | 1 | 6.80 |
| CHEMBL233025 | — | — | 1 | 6.80 |
| CHEMBL402525 | — | — | 1 | 6.75 |
| CHEMBL401814 | — | — | 1 | 6.75 |
| CHEMBL256588 | — | — | 1 | 6.71 |
| CHEMBL256386 | — | — | 1 | 6.70 |
| CHEMBL257649 | — | — | 1 | 6.60 |
| CHEMBL272494 | — | — | 1 | 6.50 |
| CHEMBL233649 | — | — | 1 | 6.45 |
| CHEMBL258157 | — | — | 1 | 6.33 |
| CHEMBL430094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272710 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL271706 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL272280 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL271878 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL403182 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL404702 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL403240 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL256022 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL403770 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL256587 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL401718 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL271454 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL272920 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL404836 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL436816 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL257647 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL256385 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL233025 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL402525 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL401814 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL256588 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL256386 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL257649 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL272494 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL233649 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL258157 | — | IC50 | = | 473.0 | nM | 6.33 |
| CHEMBL430094 | — | IC50 | > | 1000.0 | nM | - |