Assay Detail
Binding
CHEMBL930118
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Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.31 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272938 | — | — | 1 | 9.22 |
| CHEMBL404669 | — | — | 1 | 9.15 |
| CHEMBL257479 | — | — | 1 | 9.00 |
| CHEMBL255743 | — | — | 1 | 9.00 |
| CHEMBL271441 | — | — | 1 | 9.00 |
| CHEMBL255744 | — | — | 1 | 8.96 |
| CHEMBL273187 | — | — | 1 | 8.92 |
| CHEMBL256246 | — | — | 1 | 8.89 |
| CHEMBL255746 | — | — | 1 | 8.82 |
| CHEMBL404367 | — | — | 1 | 8.74 |
| CHEMBL257292 | — | — | 1 | 8.66 |
| CHEMBL255955 | — | — | 1 | 8.59 |
| CHEMBL402846 | — | — | 1 | 8.52 |
| CHEMBL404342 | — | — | 1 | 8.51 |
| CHEMBL403439 | — | — | 1 | 8.42 |
| CHEMBL256043 | — | — | 1 | 8.41 |
| CHEMBL404223 | — | — | 1 | 8.40 |
| CHEMBL256205 | — | — | 1 | 8.29 |
| CHEMBL403402 | — | — | 1 | 8.10 |
| CHEMBL258141 | — | — | 1 | 8.09 |
| CHEMBL404366 | — | — | 1 | 8.06 |
| CHEMBL256824 | — | — | 1 | 7.89 |
| CHEMBL255956 | — | — | 1 | 7.80 |
| CHEMBL439068 | — | — | 1 | 7.47 |
| CHEMBL257533 | — | — | 1 | 7.43 |
| CHEMBL256825 | — | — | 1 | 7.34 |
| CHEMBL404257 | — | — | 1 | 7.21 |
| CHEMBL272767 | — | — | 1 | 7.19 |
| CHEMBL404571 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272938 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL404669 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL257479 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL255743 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL271441 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL255744 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL273187 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL256246 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL255746 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL404367 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL257292 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL255955 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL402846 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL404342 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL403439 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL256043 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL404223 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL256205 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL403402 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL258141 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL404366 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL256824 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL255956 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL439068 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL257533 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL256825 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL404257 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL272767 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL404571 | — | IC50 | = | 99.0 | nM | 7.00 |