Compound Detail
CHEMBL256825
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Basic Information
| ChEMBL ID | CHEMBL256825 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LQMRUEJGBJTXNT-UHFFFAOYSA-N |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.8
MW (Da)
4.50
ALogP
4
HBA
4
HBD
108.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.92 | 7.63 | 12.0 | 6 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of KDR by HTRF assay | 18023347 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of KDR kinase activity (unknown origin) | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of KDR kinase activity (unknown origin) | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 46.0 | nM | 7.34 | Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells | 18023347 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 46.0 | nM | 7.34 | Inhibition of KDR (unknown origin) in cell-based assay | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 46.0 | nM | 7.34 | Inhibition of KDR (unknown origin) in cell-based assay | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-011-9926-4 | Vascular endothelial growth factor receptor 2 | 4 |
| 18023347 | 10.1016/j.bmcl.2007.10.018 | Vascular endothelial growth factor receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine