Assay Detail
Binding
CHEMBL930273
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Inhibition of recombinant GSK3-beta
151
Total Activities
151
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3beta inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 151 | 6.89 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260417 | — | — | 1 | 9.10 |
| CHEMBL261129 | — | — | 1 | 9.00 |
| CHEMBL260664 | — | — | 1 | 9.00 |
| CHEMBL407981 | — | — | 1 | 8.40 |
| CHEMBL258483 | — | — | 1 | 8.30 |
| CHEMBL260416 | — | — | 1 | 8.30 |
| CHEMBL259271 | — | — | 1 | 8.30 |
| CHEMBL261518 | — | — | 1 | 8.30 |
| CHEMBL260662 | — | — | 1 | 8.22 |
| CHEMBL264161 | — | — | 1 | 8.15 |
| CHEMBL408564 | — | — | 1 | 8.15 |
| CHEMBL407980 | — | — | 1 | 8.15 |
| CHEMBL259838 | — | — | 1 | 8.15 |
| CHEMBL409738 | — | — | 1 | 8.15 |
| CHEMBL261549 | — | — | 1 | 8.15 |
| CHEMBL260345 | — | — | 1 | 8.10 |
| CHEMBL405145 | — | — | 1 | 8.10 |
| CHEMBL406125 | — | — | 1 | 8.05 |
| CHEMBL407002 | — | — | 1 | 7.96 |
| CHEMBL261441 | — | — | 1 | 7.96 |
| CHEMBL410926 | — | — | 1 | 7.92 |
| CHEMBL408019 | — | — | 1 | 7.92 |
| CHEMBL317657 | — | — | 1 | 7.85 |
| CHEMBL260163 | — | — | 1 | 7.82 |
| CHEMBL406644 | — | — | 1 | 7.80 |
| CHEMBL407373 | — | — | 1 | 7.75 |
| CHEMBL260680 | — | — | 1 | 7.75 |
| CHEMBL261596 | — | — | 1 | 7.72 |
| CHEMBL263907 | — | — | 1 | 7.70 |
| CHEMBL352222 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260417 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL261129 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL260664 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL407981 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL261518 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL259271 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL260416 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL258483 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL260662 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL264161 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL408564 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL407980 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL259838 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL409738 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL261549 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL405145 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL260345 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL406125 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL261441 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL407002 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL408019 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL410926 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL317657 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL260163 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL406644 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL260680 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL407373 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL261596 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL263907 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL352222 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL407730 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL259744 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL427909 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL156379 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL407003 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL160586 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL260243 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL260663 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL260231 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL261659 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL406701 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL158885 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL258701 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL422714 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL345348 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL345801 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL347681 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL345212 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL156987 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL259270 | — | IC50 | = | 75.0 | nM | 7.12 |