Compound Detail
CHEMBL260664
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Basic Information
| ChEMBL ID | CHEMBL260664 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IBMFJBCXKFJOPZ-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
328.8
MW (Da)
3.33
ALogP
4
HBA
3
HBD
90.9
PSA (Ų)
0.69
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | IC50 | 9.0 | 9.0 | 1.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 9.0 | 9.0 | 1.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 alpha | IC50 | = | 1.0 | nM | 9.0 | Inhibitory activity to human glycogen synthase kinase-3 alpha (GSK-3alpha) was d... | 12941332 |
| Glycogen synthase kinase-3 beta | IC50 | = | 1.0 | nM | 9.0 | Inhibition of recombinant GSK3-beta | 18324764 |
| Unchecked | IC50 | = | 1.0 | nM | 9.0 | Inhibition of GSK3 | 17707953 |
| Unchecked | IC50 | = | 1.0 | nM | 9.0 | Inhibition of GSK3 | 17707953 |
| Glycogen synthase kinase-3 alpha | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human GSK3alpha | 29306837 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17707953 | 10.1016/j.ejmech.2007.06.016 | Unchecked | 2 |
| 12941332 | 10.1016/s0960-894x(03)00645-0 | Glycogen synthase kinase-3 alpha | 1 |
| 18324764 | 10.1021/jm7009765 | Glycogen synthase kinase-3 beta | 1 |
| 29306837 | 10.1016/j.ejmech.2017.11.103 | Glycogen synthase kinase-3 alpha | 1 |
Data from ChEMBL 36 via Core Engine