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Assay Detail

CHEMBL997785

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Binding
Inhibition of GSK3
ChEMBL ↗
154
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Selectivity criterion for pyrazolo[3,4-b]pyrid[az]ine derivatives as GSK-3 inhibitors: CoMFA and molecular docking studies.
Patel DS, Bharatam PV.
Eur J Med Chem (2008) 43 : 949 -957
PubMed 17707953 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 154 7.40 10.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35785 — — 2 10.10
CHEMBL287092 — — 2 9.96
CHEMBL38425 — — 2 9.72
CHEMBL260417 — — 2 9.10
CHEMBL39300 — — 2 9.02
CHEMBL260664 — — 2 9.00
CHEMBL261129 — — 2 9.00
CHEMBL288143 — — 2 8.40
CHEMBL407981 — — 2 8.40
CHEMBL41783 — — 2 8.30
CHEMBL260416 — — 2 8.30
CHEMBL258483 — — 2 8.30
CHEMBL261518 — — 2 8.30
CHEMBL259271 — — 2 8.30
CHEMBL260662 — — 2 8.22
CHEMBL264161 — — 2 8.15
CHEMBL407980 — — 2 8.15
CHEMBL408564 — — 2 8.15
CHEMBL409738 — — 2 8.15
CHEMBL261549 — — 2 8.15
CHEMBL260345 — — 2 8.10
CHEMBL405145 — — 2 8.10
CHEMBL406125 — — 2 8.05
CHEMBL407002 — — 2 7.96
CHEMBL261441 — — 2 7.96
CHEMBL408019 — — 2 7.92
CHEMBL410926 — — 2 7.92
CHEMBL317657 — — 2 7.85
CHEMBL500804 — — 2 7.82
CHEMBL406644 — — 2 7.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35785 — IC50 = 0.07943 nM 10.10
CHEMBL35785 — IC50 = 0.08 nM 10.10
CHEMBL287092 — IC50 = 0.11 nM 9.96
CHEMBL287092 — IC50 = 0.1096 nM 9.96
CHEMBL38425 — IC50 = 0.19 nM 9.72
CHEMBL38425 — IC50 = 0.1905 nM 9.72
CHEMBL260417 — IC50 = 0.8 nM 9.10
CHEMBL260417 — IC50 = 0.8128 nM 9.09
CHEMBL39300 — IC50 = 0.95 nM 9.02
CHEMBL39300 — IC50 = 0.955 nM 9.02
CHEMBL260664 — IC50 = 1.0 nM 9.00
CHEMBL261129 — IC50 = 1.0 nM 9.00
CHEMBL261129 — IC50 = 1.0 nM 9.00
CHEMBL260664 — IC50 = 1.0 nM 9.00
CHEMBL407981 — IC50 = 3.981 nM 8.40
CHEMBL407981 — IC50 = 4.0 nM 8.40
CHEMBL288143 — IC50 = 3.981 nM 8.40
CHEMBL288143 — IC50 = 4.0 nM 8.40
CHEMBL261518 — IC50 = 5.012 nM 8.30
CHEMBL259271 — IC50 = 5.012 nM 8.30
CHEMBL258483 — IC50 = 5.0 nM 8.30
CHEMBL261518 — IC50 = 5.0 nM 8.30
CHEMBL259271 — IC50 = 5.0 nM 8.30
CHEMBL41783 — IC50 = 5.0 nM 8.30
CHEMBL260416 — IC50 = 5.0 nM 8.30
CHEMBL260416 — IC50 = 5.012 nM 8.30
CHEMBL258483 — IC50 = 5.012 nM 8.30
CHEMBL41783 — IC50 = 5.012 nM 8.30
CHEMBL260662 — IC50 = 6.0 nM 8.22
CHEMBL260662 — IC50 = 6.026 nM 8.22
CHEMBL407980 — IC50 = 7.0 nM 8.15
CHEMBL409738 — IC50 = 7.079 nM 8.15
CHEMBL409738 — IC50 = 7.0 nM 8.15
CHEMBL407980 — IC50 = 7.079 nM 8.15
CHEMBL261549 — IC50 = 7.0 nM 8.15
CHEMBL408564 — IC50 = 7.0 nM 8.15
CHEMBL261549 — IC50 = 7.079 nM 8.15
CHEMBL264161 — IC50 = 7.0 nM 8.15
CHEMBL264161 — IC50 = 7.079 nM 8.15
CHEMBL408564 — IC50 = 7.079 nM 8.15
CHEMBL260345 — IC50 = 7.943 nM 8.10
CHEMBL405145 — IC50 = 7.943 nM 8.10
CHEMBL405145 — IC50 = 8.0 nM 8.10
CHEMBL260345 — IC50 = 8.0 nM 8.10
CHEMBL406125 — IC50 = 9.0 nM 8.05
CHEMBL406125 — IC50 = 8.913 nM 8.05
CHEMBL407002 — IC50 = 10.96 nM 7.96
CHEMBL261441 — IC50 = 10.96 nM 7.96
CHEMBL261441 — IC50 = 11.0 nM 7.96
CHEMBL407002 — IC50 = 11.0 nM 7.96